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Introduction

Mesothelioma is a cancer which affects the tissue which surrounds and protects various organs in the body. This tissue is called the Mesothelium, and Mesothelioma causes it to become abnormal, divide without control, and invade and damage nearby organs. The most common form is pleural mesothelioma which affects the sac that lines the chest cavity and protects the lungs (the pleura). Other forms are peritoneum mesothelioma (which affects the abdominal cavity) and pericardium mesothelioma (affecting the lining around the heart). The tumours can be either benign (non-cancerous) or malignant (cancerous) although they are most often malignant.

Causes

Mesothelioma is caused by the inhalation of asbestos, a fibrous carcinogenic. These fibres lodge themselves in the lining of the lung affecting the mesothelial cells. Sometimes they cause scarring of the lungs (which is called asbestosis) but this is not cancerous. They can, however, trigger tumour growth between 20 to 50 years after they are inhaled (the average is 35 to 40 years). Asbestos fibres which are swallowed can reach the lining of the abdominal cavity where they play a part in causing peritoneal mesothelioma.

It is generally the case that the longer or more intense the exposure to asbestos the more likely Mesothelioma is to occur. However, there are cases of people getting Mesothelioma years after having worked with it for just a few months. The families of asbestos workers are also at risk as they would possibly have been exposed to asbestos fibres on the clothing of their loved ones.

The dangers of asbestos are now well known, but this was not always the case. Before the 1970s asbestos was a primary insulating material with little or no control in its use or handling. The resulting increase in cases of Mesothelioma is a direct cause of these past practices.

Symptoms

Mesothelioma is often advanced before symptoms occur. This means that the prognosis is not usually very good, with the average survival time for all stages of Malignant Mesothelioma being about one year. Symptoms resemble pneumonia, which coughs, breathing difficulties and abdominal pain being common.

Treatments

Mesothelioma can be treated by chemotherapy, radiotherapy or surgery, or a combination of the three.

Surgery
Extra pleural pneumonectomy is where the entire lung and a portion of the lining of the chest, the diaphragm, and some or the entire sac which surrounds the heart is removed.

Wide local excision targets and removes the cancer and a limited amount of the healthy tissue surrounding the cancerous region.

Pleurectomy and decortication removes part of the covering of the lungs, as well as the lining of the chest and portions of the outside covering of the lungs.

Pleurodesis uses a blend of chemicals and/or drugs to create an intentional scar between the layers of the pleura. Post surgery, the space created by the scar must be drained, using either a catheter or chest tube, and is then filled with a chemical which inhibits the accumulation of fluid in the pleura cavity.

Radiation Therapy
Radiation Therapy uses high energy x-rays to kill cancer cells.

In External radiation therapy a machine emits radiation in a targeted stream at a certain portion of the body.

Internal radiation therapy uses needles, seeds and catheters to place radioactive substance directly on or near the cancer.

Chemotherapy
Chemotherapy uses cancer targeting drugs to stop the cells them from dividing and thus prevent their growth.

Asbestos is a natural mineral that was once used in the construction and home improvement industries. It was put on ceilings when it was mixed with aertex, it was used to make surfaces semi flame resistant and it was also mixed with cement as it is very strong. At one point asbestos was seen as a revolution for these industries as it was just so versatile ? it was also deadly. No one realised at the time that every time they were exposed to asbestos that they were taking their life in their hands and putting themselves in grave danger. Asbestos is now banned but its legacy lives on in the thousands of people who are feeling the after effects of being exposed to it over the years.

Exposure to asbestos is directly related to certain types of cancer, including peritoneal mesothelioma which is cancer of the membranes in the abdominal cavity. Peritoneal mesothelioma is the second rarest form of mesothelioma and each year it is responsible for around 20% of the cases of diagnosed mesothelioma. As exposure to asbestos is the only known cause of peritoneal mesothelioma there are two main ways that doctors believe that it can actually reach the abdominal wall. One way is through the digestion of asbestos fibres which is actually easy than most might think. Once in the digestive system the asbestos fibres get stuck in the peritoneum and over time this can result in peritoneal mesothelioma. The second way that asbestos gets to the abdomen is through the lymph nodes and lungs when asbestos is inhaled. In some cases pleural mesothelioma will result in peritoneal mesothelioma ad the asbestos moves through the lungs and into the abdominal cavity if left untreated and undiagnosed for some months.

Suspicion of peritoneal mesothelioma is usually made when a patient exhibits signs such as pain in the abdomen, chest or stomach and many suspect hernias are actually created by a tumour caused by peritoneal mesothelioma. Often a misdiagnosis that does not include peritoneal mesothelioma can be made and this can have severe repercussions on the life expectancy of a patient. It is usual for someone who is thought to have peritoneal mesothelioma to have to undergo many tests to get a correct diagnosis and these tests are imaging scans and tissue biopsies.

Patients who are found to have peritoneal mesothelioma do not have a good prognosis. However if a diagnosis of peritoneal mesothelioma is made early enough they could have surgery to remove the disease and some cases it can extend a patient?s life span for a few more years. If surgery is not an option then chemotherapy or radiotherapy can help although there is no guarantee that this will make much of a difference. It is essential that a person with peritoneal mesothelioma gets the right kind of treatment for any pain that they experience so that they are as comfortable as they can be. Peritoneal mesothelioma, like the other forms of mesothelioma is highly unpleasant and hard to live with.