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Peritoneal Mesothelioma is a type of cancer that affects the peritoneum of the human abdominal cavity. Hence, this medical condition is also called as abdominal mesothelioma.

But before seeing more about peritoneal mesothelioma, let us first take a look at the classifications and functions of the peritoneum membrane.

Peritoneum is classified into visceral and parietal peritoneum. The visceral peritoneum envelops the abdominal organs and forms the periphery of the intestinal tract. On the other hand, parietal peritoneum covers the abdominal cavity. The purpose of these layers is to protect the internal organs and to secrete a lubricating fluid that eases the movement of internal organs in the abdominal cavity.

Causes of Peritoneal Mesothelioma

Even though not a definitive explanation, it is widely considered that asbestos is the main cause for peritoneal mesothelioma. According to medical experts, in two ways asbestos dust could reach the intestine lining one through involuntary ingestion during working long hours and days amid asbestos, and secondly, through the lungs while breathing and hence along the lymph nodes to the peritoneal cavity. Either way, it is injurious to the human body, and may invariably lead to this cancerous condition if exposed to for a longer period of time.

Symptoms of Peritoneal Mesothelioma

Peritoneal mesothelioma, like the other forms of mesothelioma, shows a very long latency period and it wont be until 20-30 years since the asbestos-exposure days before any typical symptoms becomes apparent. But by then it will be too late to check the disease or provide any constructive medication or treatment. Further, a delay in diagnosing the disease can happen due to the fact that most of the symptoms of mesothelioma is not-specific and may resemble that of some other common and less serious diseases. For example, the common mesothelioma symptoms include anemia, fever, weight loss, abdominal pain, and bowel obstruction, and it is highly likely that the doctor initially may consider other options than contemplating cancer. Therefore, the patient telling the doctor about any previous asbestos exposure in the first one-to-one interaction itself is very crucial, and that helps the doctor to think of a possible mesothelioma threat even before considering other possibilities.

Treatments

Once the disease has been diagnosed, the doctor recommends the treatments based on several factors such as the extent of the damage, age and medical history of the person and overall health. The traditional treatments for mesothelioma include surgery if the tumor has spread out and is beyond radiation-curable radiation therapy, external and internal radiation, and chemotherapy, which includes using a pill or needle to insert anti-carcinogen drugs into the body.

With the advancement in science and technology, newer treatment techniques have been introduced, and some of it is looking promising as well.

Intraoperative photodynamic therapy is one such newer method that uses special drugs and light to destroy cancer cells. This method is used to study the earlier phases of mesothelioma in the chest.

Further, Immunotherapy is a way of boosting the immunity of ones own body against the spread of cancer. Also, recently, researches have found that Gene Therapy is effective in correcting the faulty genes causing mesothelioma. But these two methods are still in the clinical trials and are yet to be implemented in hospitals.

Even though a wide range of treatments are available for mesothelioma, clinical experiences reveals that none of this alone is capable of checking the disease effectively. Therefore, it is a selected combination of some of these treatments called the “multimodality approach” that is commonly followed and the different modes of treatments to be used are decided by the doctor based on the given medical condition of the patient and his/her age.

Tail Piece Passive exposure to asbestos can also lead to mesothelioma. This happens when asbestos fibers reach the domestic setup through clothes dirties with asbestos dust. Therefore it is advisable that those handling asbestos may change their clothes before returning home or going to any public place.

One rare form of cancer is called Mesothelioma, a malignant tumor in the mesothelial tissues of the lungs and the abdomen, arising from the inhalation of asbestos. Its rarity is one of the reasons why a lot of people are not aware of this kind of fatal disease. In fact, many people die of Mesothelioma undiagnosed. Although there is now a growing awareness of the hazards of asbestos to health, still many have not heard of Mesothelioma and thus, have not understood its nature, cause, signs and treatment. Even some physicians find it hard to detect Mesothelioma because its symptoms are akin to other diseases like lung cancer and pneumonia. Furthermore, it takes decades for a patient who was exposed to asbestos to develop Mesothelioma ? fifty years, at most.

Being unaware of Mesothelioma poses higher risks since it deters diagnosis and treatment. A person undergoing treatment must know the different stages of the cancer or the extent of the disease. Chances of recovering from Mesothelioma and the kind of treatment depend on the stage of the illness. There are basically two staging systems used for Pleural Mesothelioma (lungs): TNM system and Brighan system. These staging systems are also used in other kinds of cancers; however, the first is commonly used. There is no established method in determining the stage of the Peritoneal Mesothelioma cancer (abdominal) so the TNM system is used.

There are three variables in the TNM system: tumor, lymph nodes and metastasis. In the earliest stage of Mesothelioma, stage I, the malignant Mesothelioma cells start to grow and multiply only one layer of the pleura. The pleura is the membrane that encloses the lungs and lines the wall of the chest cavity. However, there are some instances wherein the pericardium (membrane that covers the heart) and diaphragm cover are already affected. In this case, the cancer patient is still in stage I Mesothelioma.

In the second stage, the two layers of the pleura are already affected by Mesothelioma. Take note, however, that in this stage, only one side of the body is affected. Normally, the pleura produces only small amount of lubricating fluid that allows easy expanding and contracting of the lungs. The excess fluid is absorbed by the blood and the lymph vessels so there?s a balance between the amount of fluid produced and removed. During the second stage Mesothelioma, fluid starts to build up between the membrane of the lungs and the membrane of the chest wall, resulting to pleural effusion. The increase in the volume of fluid produced causes shortness of breath and chest pain. Other Mesothelioma cancer patients experience dry and persistent cough. Diagnosis of the pleural effusion is achieved through a chest x-ray.

Stage III Mesothelioma means that the malignant cells have already spread to the chest wall, esophagus and the lymph nodes on one part of the chest. The patient may suffer severe pain near the parts affected. When not treated immediately or when the Mesothelioma patient doesn?t respond well to medication, the cancer may advance to the fourth stage. The fourth stage Mesothelioma is formidable since at this stage the Mesothelioma cells have penetrated into the bloodstream and other organs in the body like the liver, the bones and the brain. The lymph nodes on the other side of the chest may also be affected by Mesothelioma in stage IV.

Brighan staging system, on the other hand, determines whether the Mesothelioma can be surgically removed or not and whether the lymph nodes are affected or not. In stage I Mesothelioma, the lymph nodes are not yet affected and the patient can still recover through surgery. In stage II, surgery can still be executed but some lymph nodes have already been infiltrated by the cancer cells. In stage III, the heart and chest wall are already affected; thus, surgery is no longer advisable. The lymph nodes in this stage, however, may or may not be affected. In the final stage, stage IV Mesothelioma, cancer cells have already gone to the bloodstream and other parts of the body like the heart, brain, bone and liver. In most cases, a patient who has reached stage IV Mesothelioma only has four to twenty-four months to live.

Asbestos is a natural mineral that was once used in the construction and home improvement industries. It was put on ceilings when it was mixed with aertex, it was used to make surfaces semi flame resistant and it was also mixed with cement as it is very strong. At one point asbestos was seen as a revolution for these industries as it was just so versatile ? it was also deadly. No one realised at the time that every time they were exposed to asbestos that they were taking their life in their hands and putting themselves in grave danger. Asbestos is now banned but its legacy lives on in the thousands of people who are feeling the after effects of being exposed to it over the years.

Exposure to asbestos is directly related to certain types of cancer, including peritoneal mesothelioma which is cancer of the membranes in the abdominal cavity. Peritoneal mesothelioma is the second rarest form of mesothelioma and each year it is responsible for around 20% of the cases of diagnosed mesothelioma. As exposure to asbestos is the only known cause of peritoneal mesothelioma there are two main ways that doctors believe that it can actually reach the abdominal wall. One way is through the digestion of asbestos fibres which is actually easy than most might think. Once in the digestive system the asbestos fibres get stuck in the peritoneum and over time this can result in peritoneal mesothelioma. The second way that asbestos gets to the abdomen is through the lymph nodes and lungs when asbestos is inhaled. In some cases pleural mesothelioma will result in peritoneal mesothelioma ad the asbestos moves through the lungs and into the abdominal cavity if left untreated and undiagnosed for some months.

Suspicion of peritoneal mesothelioma is usually made when a patient exhibits signs such as pain in the abdomen, chest or stomach and many suspect hernias are actually created by a tumour caused by peritoneal mesothelioma. Often a misdiagnosis that does not include peritoneal mesothelioma can be made and this can have severe repercussions on the life expectancy of a patient. It is usual for someone who is thought to have peritoneal mesothelioma to have to undergo many tests to get a correct diagnosis and these tests are imaging scans and tissue biopsies.

Patients who are found to have peritoneal mesothelioma do not have a good prognosis. However if a diagnosis of peritoneal mesothelioma is made early enough they could have surgery to remove the disease and some cases it can extend a patient?s life span for a few more years. If surgery is not an option then chemotherapy or radiotherapy can help although there is no guarantee that this will make much of a difference. It is essential that a person with peritoneal mesothelioma gets the right kind of treatment for any pain that they experience so that they are as comfortable as they can be. Peritoneal mesothelioma, like the other forms of mesothelioma is highly unpleasant and hard to live with.

I’m doing some research and have heard that it’s common for mesothelioma, in more advanced stages, to metastasize to the lungs. What symptoms does this cause for the patient?
Thank you in advance.